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Safety Overall, tirzepatide was well tolerated in the SURMOUNT clinical trial program

Easy injections and a user-friendly program appeal to you

Side Effects of Tirzepatide and Semaglutide These medications arent silent passengersthey come with a few bumps along the way, especially during the first few weeks or when your dose increases: nausea: a rolling, unsettled stomach that may show up right after meals or linger all day vomiting: especially after overeating or with certain foods bloating: a tight, uncomfortable feeling in your midsection gas: often unexpected and frequent constipation: hard stools or fewer bowel movements than usual diarrhea: loose or urgent stools, sometimes alternating with constipation loss of appetite: you forget to eat, or food just doesnt appeal anymore fatigue: a general sense of low energy or sluggishness, especially early on burping or acid reflux: a burning sensation or repeated belching after meals mild headache: usually short-lived and manageable with rest or hydration injection-site soreness, redness, swelling, or itching: typically mild and short-lived These symptoms often peak during dose escalation and tend to ease as your body adjusts

Appetite may return more fully

Maintaining adequate hydration and promptly reporting symptoms such as decreased urination, dark urine, or persistent dizziness to your healthcare provider is important for kidney safety monitoring

Before reconstitution, lyophilized tirzepatide can remain stable for 12 to 24 months when stored in the refrigerator