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The authors of the JAMA Ophthalmology paper state they do not have a defined mechanism

in clinical use, the best-known GIP-related medication is tirzepatide, sold as Mounjaro for type 2 diabetes and Zepbound for weight management, and it is called a dual GIP/GLP-1 receptor agonist because it acts on both pathways
Severity and Discontinuation 13 events were mild 7 events were moderate 1 event was severe and serious Two discontinuations, both in the 12 mg group: One due to QT interval prolongation One due to moderate palpitations Types of Reported Arrhythmia-Related Events (Frequency varies by dose
(Graphic: Business Wire) These outcomes stand in stark contrast to other real-world results of GLP-1 weight loss treatments
Supernatant was filtrated and collected for analysis using LC-MS platform