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These results suggest that exendin-4-induced suppression may be mediated by a distinct Gs/cAMP-PKA/IP3/Ca2+/CaM/CaMKII signaling pathway, following the activation of GLP-1Rs.

Methods This retrospective cohort study included data on US adults with T2D receiving SGLT2i from Komodos Healthcare Map from January 1, 2017, to June 30, 2023