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A study of nearly 1.1 million people found that semaglutide (the drug in Ozempic and Wegovy) was associated with a 40-70% lower risk of developing Alzheimer's compared to other diabetes medications

While the overall frequency of liver enzyme elevations across the over 1,400 participant safety database of danuglipron is in-line with approved agents in the class, a single asymptomatic participant in one of the dose-optimization studies experienced potential drug-induced liver injury which resolved after discontinuation of danuglipron

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These adaptations position irisin as a promising therapeutic target for preventing metabolic disorders and optimizing exercise protocols