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The messenger RNA expression levels of the (A) ACAT1, (B) SREBP-2, (C) HMGCR, (D) SQLE, (E) LXR, (F) CYP7A1, (G) LDLR, (H) PCSK9, (I) SR-B1, and (J) ABCA1 genes were analyzed by quantitative real-time polymerase chain reaction and normalized to that of the ACTB gene

Lancet 384:22282234

[2] There is no UK Summary of Product Characteristics (SmPC) or EMA EPAR, and use is currently limited to clinical trials

Neurosci Lett (1998) 240(2):1102

What factors should providers consider when initiating semaglutide therapy in a patient like Richard regarding his comorbid conditions and previous treatment outcomes