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The trial demonstrated that approximately 35% of semaglutide-induced weight loss was due to loss of lean mass and further demonstrated that combining semaglutide with trevogrumab with or without garetosmab helped preserve lean mass while increasing loss of fat mass

Cardiovascular Support: Beyond glucose control, this medication is used to reduce the risk of serious heart-related events in high-risk patients

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Taking semaglutide (Ozempic) and tirzepatide together is not clinically advised due to overlapping mechanisms and safety concerns

Conclusions/interpretation Our findings do not support an increased risk of SIS when taking GLP-1RA in individuals with type 2 diabetes and obesity