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1 Vascular-barrier effects: less blood-brain barrier disruption, a pathway that could affect edema, hemorrhagic transformation risk, or downstream immune-cell entry

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However, given that neither hypothalamic (Nkx2.1 neurons), PVN (Sim1 neurons), nor POMC neurons were not necessary for the ability of long-acting agonists to reduced body mass (18), the hunt is still on for the specific population of neurons responsible for the pharmaceutical reduction in body mass

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