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GLP-1 RAs do not only act on insulin secretion but also have a wide spectrum of pleotropic action that is reported in Fig

Despite this broad therapeutic interest, certain domainsparticularly skeletal muscle biology and neurodegenerationillustrate a recurring translational mismatch between mechanistic signaling effects and clinical functional outcomes

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This is essential before starting medication that carries a thyroid cancer warning Rule out MTC/MEN2: Confirm no personal or family history of medullary thyroid carcinoma or MEN2

Tettamanti et al