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Cost, side effects, supply issues, and simple fatigue with long-term injections all play a role
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Metformins most common side effect is GI distress: nausea, loose stools, abdominal cramps, especially in the first 2 to 4 weeks

Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

[DOI] [Google Scholar] 256.Prins PJ, Noakes TD, Buga A, et al
