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[4] [5] Imbalanced GLP-1 function may manifest as either insufficient production or impaired receptor sensitivity, though there is no official clinical definition of "GLP-1 imbalance" as a distinct diagnostic entity

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4 Key secondary endpoints included 4 : Noninferiority of tirzepatide 5 mg once weekly to semaglutide 1 mg once weekly for glycemic control at 40 weeks