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Small peptides like GLP-1 and GLP-2 are rapidly cleared in vivo , leading to low circulating levels

Phentermine-Topiramate: 10-15% body weight loss on average

Over the past decade, they have also shown significant impact on weight loss

doi: 10.2337/db09-1694 [DOI] [PMC free article] [PubMed] [Google Scholar] 60

Even once approved, insurance coverage will depend on cost-effectiveness analyses, formulary negotiations, and clinical positioning relative to tirzepatide and semaglutide

It comes as rivals Eli Lilly and Novo Nordisk have been racing to get their obesity pills to market, as they seek to expand their offering amid booming demand for their GLP-1 treatments