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The SELECT trial, which supports the expanded indication, enrolled patients 45 years of age and older with pre-existing cardiovascular disease and a body-mass index of 27 or greater without diabetes

[80] The trial reported cumulative occurrence of major adverse cardiovascular events, a primary end-point event of the trial, for 569 of the 8803 patients in the semaglutide group, which were 6.5% of the participants, and for 701 of the 8801 patients in the placebo group, which were 8% of the participants, showing relative 18.8% less major adverse cardiovascular events, such as death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, occurring for participants who had received semaglutide in the trial relative to those who had received placebo over the course of around 48 months, or 34.213.7 months, which was the mean (SD) total duration of the participants in either group's exposure to the placebo or semaglutide during the trial

Allergic contact dermatitis has also been implicated in some types of scarring alopecias, especially frontal fibrosing alopecia (FFA) and lichen planopilaris. Consider patch testing in recalcitrant patients, she advises, as well as in those who wash their hair or scalp daily but report increased itching afterward

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