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Cost Impact and Equity of Access The high cost of GLP-1RAs presents a significant barrier to widespread access, especially in LMICs

Chronic sleep disruption is associated with lower Akkermansia muciniphila populations in the gut microbiome, which creates a double hit, reduced GLP-1 sensitivity plus reduced microbial GLP-1 stimulation

One concerning effect of GLP-1RA is delaying gastric emptying, leading to increased gastric volumes, and putting patients at risk for aspiration during anesthesia and/or sedation (Beam 2023

The increased ICP in IIH is thought to stem from impaired cerebrospinal fluid (CSF) absorption, possibly due to elevated venous sinus pressure

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Both drugs are given as a once-weekly subcutaneous injection