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It is being studied for obesity, T2D, MASLD, obstructive sleep apnea, and knee osteoarthritis linked to obesity.[4] Eli Lilly began developing retatrutide after the early commercial success of tirzepatide (the dual-agonist molecule that became Mounjaro and Zepbound) signaled that adding more hormone-receptor targets to a single molecule could push weight loss meaningfully higher than what a GLP-1 drug alone could deliver

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doi: 10.2337/dbi17-0013

But mechanistic plausibility is not clinical proof

References 1.Holst JJ
