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Although no medication is specifically approved to treat IR, we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin sensitivity

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Retatrutide is studied in research settings because of its relationship with GLP-1, GIP and glucagon receptor pathways

Male SpragueDawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic rats treated with Retatrutide (STZR), and sham rats treated with Retatrutide alone (R)

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