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Description
The new oral tablet is also indicated for reducing the risk of major adverse cardiovascular (CV) events in adults with established CV disease who have obesity or overweight

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Background Oral semaglutide is a novel glucagon-like peptide-1 (GLP-1) analog that has been associated with improvements in glycated hemoglobin (HbA1c) and body weight versus sodium-glucose cotransporter-2 inhibitor empagliflozin and injectable GLP-1 receptor agonist dulaglutide in the PIONEER 2 clinical trial and in a recent network meta-analysis (NMA), respectively
Following the initial top-line readout in August which showed a statistically significant, 20% relative risk reduction in MACE-3 cardiovascular events the veil has finally been lifted from the landmark SELECT cardiovascular outcomes trial

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