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Although rarely acknowledged, case reports and emerging evidence suggest GLP-1 receptor agonists may contribute to bowel obstruction

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Whilst the medication does not directly affect fluid balance, its gastrointestinal effectsincluding nausea, vomiting, and diarrhoeacan lead to fluid losses requiring conscious replacement

Analyzing these patents revealed that Chugai Pharmaceutical Co., Ltd., aside from its core patent WO2018056453A1 and its family members, has no other patents related to Orforglipron

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