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NICE guidance (NG28) provides a structured approach to type 2 diabetes management, with treatment intensification based on individual patient factors including HbA1c levels, cardiovascular risk, and tolerability

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The expression of CYP19A1 in the ovarian tissue of PCOS mice was decreased, whereas that of StAR and CYP17A1 was significantly increased

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For current practice, the most defensible use of GLP-1RAs is as a time-bounded metabolic optimization strategy in women with meaningful obesity/insulin-resistance burden, with reproductive endpoints interpreted as potential downstream gains rather than guaranteed direct effects (17, 111, 112, 124)