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The beneficial effect of TZT in T2DM and obesity is related to direct activation of GIP and GLP-1 receptors with subsequent improvement of insulin sensitivity and reduction of body weight

Regarding adverse events, one thing stands out is dysesthesia which occurred in 8.8% and 20.9% (9 mg and 12 mg, respectively) of patients, compared to 0.7% with placebo

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As the fast ended for surgery rather than intolerance, research into longer water fasts could be considered.

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This article examines current evidence, provider assessment frameworks, and why individualized medical guidance is essential for pregnant or planning-pregnancy patients