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Overall, semaglutide showed superior efficacy in improving glycemic control and weight loss in patients with type 2 diabetes, and its safety and tolerability were consistent with other glucagon-like peptide-1 receptor agonists [11]

This oxidative stress-mediated autophagy effect was significantly attenuated by GLP-1 treatment

Effects of Glucagon Like Peptide-1 Receptor Agonists on the Neurological System Autoradiography of human tissue sections with 125 I-labelled GLP-1 (7-36 amide) revealed a high content of GLP-1R in the central nervous system suggesting its potentially important role in the nervous system (28)

In the STEP 1 clinical trial (using Wegovy), participants who discontinued semaglutide after one year of treatment regained roughly two-thirds of their initial weight loss over the following year

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