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Furthermore, the discovery of miRNAs as modulators of GLP-1 signaling opens exciting avenues for future research

calc: value calculated considering reported mean baseline and mean absolute change

In the context of weight loss, compounded versions of tirzepatide or semaglutide may be offered when branded medications are unavailable, backordered, or cost-prohibitive

It should not be prescribed for weight loss in people without diabetes

In all SURPASS programs, tirzepatide demonstrated a much greater HbA1c-lowering impact than placebo or active comparators, such as basal insulin and GLP1RAs [83, 86]
