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The KIT gene controls mast cell creation from stem cells in the bone marrow, and mutations in KIT cause excess mast cell proliferation.[ref][ref] A mastocytosis diagnosis is either systemic mastocytosis (affecting the whole body) or cutaneous mastocytosis, which has more skin-related symptoms

Of note, some of the studies included longer time points, up to 52 or 78 weeks, but these assessments were not controlled for multiplicity

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Filaggrin mutations associated with skin and allergic diseases

[1] [3] Regular eye screening as per NICE guidelines for diabetes care remains essential