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Moreover, gut-derived GLP-1 interacts with the brain by GLP-1R expressed in innervating fiber neurons44), where the blood-brain barrier has enhanced permeability

Both medications are dosed weekly, but semaglutide maintains higher residual levels at the end of each dosing interval relative to its peak

Double and triple agonists, which target many hormone pathways concurrently, represent the next step in pharmacotherapy, expanding on this success

Women, in particular, may notice more significant hair thinning due to a lack of iron, a common issue among those with restricted diets

Retatrutide , a triple agonist targeting GIP, GLP-1, and glucagon receptors, is in clinical development and has shown remarkable results in early trials

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.fda, cder