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The jury is out at the moment, but their potential to be differentiated from injectable peptides is clear and seems likely to drive significant research into small molecule modulators of GLP-1 for the treatment of diabetes, obesity and perhaps addictive behaviours for many years to come.

"We need more data on the long-term effects and other outcomes related to cardiovascular health, particularly in lower-risk individuals," says Eva Madrid, co-lead researcher from the Universidad de Valparaso, Chile

The improvements in sperm count, provide hope that these medications can offer more than just metabolic benefits

Harvard Health: Understanding New Weight Loss Drugs Mayo Clinic: Considering GLP-1 Medications

Pharmacol Ther 239:108270

Consult your healthcare provider if you are considering either drug, switching from one to another, or would like to explore other treatment options