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However, extrapolating these findings to human physiology is problematic due to significant species differences in pancreatic anatomy, GLP-1 receptor distribution, and metabolic responses

Treatment with GLP-1RAs can reduce monocyte/macrophage accumulation in the arterial wall by inhibiting the adhesion of monocytes to activated endothelium from the arteries of C57BL/6 mice as well as in ApoE -/- mice [64]