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Studies have shown that insulin resistance in the brain contributes to dopaminergic neuron vulnerability, promoting oxidative stress, mitochondrial dysfunction, and protein aggregation (55)
Risk of diabetic retinopathy and diabetic macular oedema with sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in type 2 diabetes: a real-world data study from a global federated database

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[Thus,] the scope of these drugs and the potential benefit of these drugs is likely to be much broader than what was originally described.

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