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The rise of biologics, including recombinant proteins, gene therapies, and cell therapies, is reshaping the landscape of modern therapeutics, offering new strategies to address previously undruggable targets

Constitutive hGPR17L activity inhibited GLP-1 secretion, and MDL29,951 treatment further inhibited this secretion, which was attenuated by treatment with the GPR17 antagonist HAMI3379

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JAMA Psychiatry Editor in Chief Dost ngr, MD, PhD, explains why his 2025 pick for Editors Choice: Clinical Trials of the Year is a randomized clinical trial showing that semaglutide is safe and effective in patients with schizophrenia who also experience overweight or #obesity and #prediabetes
