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Retatrutide drives the caloric deficit through profound appetite suppression and increased energy expenditure

Dawson TM & Dawson VL (2025)

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In STEP-1, semaglutide reduced both SBP and DBP compared with placebo

The remaining gap goes to Yucca and a handful of others who can still operate under the documented-medical-need exception

This underscores the need to identify susceptible individuals via targeted screening programs and to develop non-invasive and efficacious interventions to avoid the morbidity and premature mortality associated with HH