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It has also been suggested that brain penetrance differs between different GLP-1 analogs, with nonacylated and non-PEGylated analogs like exendin-4 or lixisenatide showing significant rates of brain influx, while liraglutide or semaglutide do not have reliable BBB crossing (143), at least in male mice

and 5) the baseline data were complete and included the number of observations, source of cases, follow-up time, and other indicators

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Finally, stroke especially affects the elderly, and additional studies in older mice should be performed