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82 The direct impact of GLP-1RAs on significant renal outcomes remains uncertain

Retatrutide Phase 2 data showed insulin resistance reductions of over 50% from baseline at higher doses, with fasting insulin levels dropping by up to 71%

Causal factors for knee, hip, and hand osteoarthritis: a Mendelian randomization study in the UK biobank

There are currently no FDA-approved GLP-1 receptor agonists that can be administered orally

While specific guidelines on continuing therapy after HbA1c normalization are lacking, current evidence supports ongoing use of these agents due to their insulin-independent mechanisms of action

adults are obese