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In MASLD, GLP-1RAs and co-agonists (GLP-1/GIP or GLP-1/glucagon) have shown efficacy in reducing hepatic fat, improving fibrosis, and resolving steatohepatitis, with promising results from trials such as ESSENCE and SYNERGY-NASH

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Estrogen receptors are expressed in the choroid plexus epithelial cells, however, and their potential involvement in CSF secretion is an interesting avenue for future studies (56,57)

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