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It found that these drugs may slightly increase the chance of getting gallstones (cholelithiasis) and acid reflux (GERD)

Metabolism becomes less efficient

Many patients tolerate these medications well, especially when doses are increased slowly

Tirzepatide and retatrutide are two of the most studied next-generation incretin mimetics, each engineered to engage multiple metabolic receptors simultaneously

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3 Mild to moderate gastrointestinal side effects are common for most patients on GLP-1s, prompting careful dose titration and monitoring