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Patients in Ro's study lost an average of 16.6% of their body weight over 68 weeks

Mir Ali , MD, medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA

50 A recent meta-analysis including thirteen RCTs has shown that semaglutide and tirzepatide treatment significantly increases GI side effects such as nausea, vomiting, diarrhea, and constipation in obese individuals without diabetes compared to control groups

For many patients, this can lead to: Loose or sagging skin Hollow cheeks or temples Increased fine lines and wrinkles Crepey skin texture Loss of facial definition Deflated appearance in areas like the breasts or buttocks These changes are not caused by the medication itself as much as they are the result of rapid weight loss

Using a lower dose of medication will slow weight loss, but it may cause fewer cosmetic side effects

For Women Over 35 Advanced maternal age adds time pressure to the equation: The age-vs-optimization dilemma: Heres the reality: your eggs are aging whether youre on GLP-1s or not
