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Indias Patents Act Section 3(d) which prohibits patents on new forms of known substances unless they demonstrate significantly enhanced efficacy addresses small-molecule formulation evergreening but was not designed for device patents

doi: 10.1046/j.1365-2125.1999.00928.x

By using chronic nitroglycerin injection-stimulated mouse model, it was observed that Liraglutide suppressed the nitroglycerin-induced upregulation of microglia in these mice, shortening both total and mean lengths of microglial processes and reduced nitroglycerin-induced upregulation of Iba-1, as well as, IL-1 and TNF- protein levels (Jing et al., 2021)

doi: 10.3389/fendo.2019.00862 86 PivonelloRIsidoriAMDe MartinoMCNewell-PriceJBillerBMKColaoA