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As potency improved to below 100 nM in the absence of BETP, the impact of the PAM gradually diminished (Fig
Corroborating these findings, other GLP-1RAs have similarly shown neuroprotective properties in murine models of ocular hypertensive glaucoma, manifesting as enhanced RGC survival, reduced microglial/macrophage activation, and amelioration of optic nerve axon degeneration [46]
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Key Takeaways GLP-1based compounds influence not only appetite but also reward and motivation pathways in research subjects
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