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The week between medications is brief enough that significant regain is unlikely

Gastrointestinal symptomsparticularly nausea, reduced appetite, and occasional vomitingare most common during the first few weeks and with each dose increase

(A different version of tirzepatide, Mounjaro, was approved by the FDA in May 2022 for type 2 diabetes management in adults, as a way to improve blood sugar when combined with diet and exercise.) In December 2024, Zepbound was also approved for the treatment of moderate to severe obstructive sleep apnea in adults with obesity

Lightheadedness is not a direct pharmacological effect listed in FDA labeling but occurs indirectly through hypoglycemia (especially with insulin or sulfonylureas), dehydration from gastrointestinal side effects, or orthostatic hypotension related to weight loss and metabolic changes

At Michigan Weight Loss Institute, we take a different approach

Brandi Addison is a speaker for Eli Lilly and Company, Novo Nordisk and Corcept Therapeutics and is an advisory board member for Eli Lilly and Company