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all should be discontinued when pregnancy is recognized) [1] [4] After prolonged treatment interruptions (typically 2 consecutive missed doses or longer gaps), re-titration from the initial dose may be necessary according to product-specific guidelines to minimize gastrointestinal side effects

Weight loss Available in NZ = Liraglutide high dose (Saxenda, daily injection) Self-funding needed ($500-600/month) Not available in NZ = Semaglutide (Ozempic, Wegovy) or Tirzepatide (Mounjaro), as of May 2023 Side effects, particularly upper gastrointestinal, are common with GLP-1 agonist initiation

This third mechanism likely explains the additional 23% weight loss beyond tirzepatide

Other trials are investigating their metabolic and non-metabolic (that is, disease specific) effects in a variety of chronic illnesses including kidney and liver disorders, Alzheimers dementia and schizophrenia 23,24

In animals with diabetes, GLP-1 agonists improve the function of insulin-producing beta cells in the pancreas

revenue dipped 8% to $530 million in Q1, while international revenue jumped nearly tenfold to $78 million in the quarter