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GLP-1R agonists effects on cardiovascular events The first pieces of evidence of the potential clinical benefit of GLP-1 agonists have emerged recently, pointing to a decrease of major adverse cardiovascular and cerebrovascular events (MACCE) including stroke, MI, cardiac mortality, acute coronary syndrome, and revascularization procedures

Looking at the imaging data, a clinically significant reduction in liver fat content based on MRI-PDFF ranged from 57% to 67% in participants receiving survodutide compared to 14% of those on placebo

Mechanistically, research shows that GLP-1 agonists can modulate the gut microbiome composition, enhance intestinal barrier function through increased mucin production, and reduce inflammatory cytokines implicated in IBS pathogenesis

With aging, impairments in mitochondrial efficiency are associated with increased reactive oxygen species (ROS) production and declining bioenergetic capacity [10]

The pen allows for subcutaneous administration, meaning the medication is injected just under the skin
