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Statistical Analysis Continuous variables are presented as mean (SD), and categorical variables are presented as number (%)

It was not possible to match HbA 1c to a mean value between cohorts

Smaller meals, steady hydration, and dietary fiber help with the common gut symptoms

However, because retatrutide is investigational and not commercially available, any switch would currently require enrollment in a clinical trial or use of compounded/research peptide sources

Key Points: Oral Semaglutide (GLP-1 receptor agonist) can provide greater HbA1c reduction, promote weight loss, and offer cardiovascular benefits in patients with established heart disease

The mechanism of action of GLP-1 agonists involves binding to GLP-1 receptors on pancreatic beta cells, which stimulates glucose-dependent insulin secretion