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At the higher weight loss dose of 2.4 mg weekly, semaglutide reduced MACE by 20% (HR 0.80, p less than 0.001) and all-cause mortality by 19%

The other remains locked behind clinical trial gates, with FDA approval still on the horizon

While the metabolic benefits of semaglutide are well-established and widely exploited in clinical practice, its influence on brain reward pathways has sparked intense scientific curiosity

However, the differences in weight loss did not translate to significant changes in the risk of obesity-related cancers or, for lung cancer, a non-obesity-related tumor

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