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In November 2023, a new GLP-1, called tirzepatide (Zepbound, Mounjaro), was approved for weight loss and obesity management

Dosing Protocol Retatrutide was administered as a once-weekly subcutaneous injection with a carefully designed titration schedule to minimize side effects: Weeks 1-4: 2mg Weeks 5-8: 4mg Weeks 9-12: 6mg Weeks 13-16: 9mg (for 9mg group) or continue to 9mg (for 12mg group) Week 17+: 9mg maintenance (9mg group) or 12mg maintenance (12mg group) This gradual dose escalation over 12-16 weeks helped participants build tolerance to the medication's gastrointestinal effects while the therapeutic benefits accumulated

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Older Adults: Prioritize agents with benign CNS profiles (e.g., orlistat, low-dose liraglutide)

I've spent years managing temperature-sensitive injectable medications while traveling