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patent describes new glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of diabetes type 2, hyperglycemia and obesity.

A large-scale study suggests that GLP-1 drugs could have unexpected mental health benefits, including lower risks of depression, anxiety, and substance use.

In conclusion, the paper provides evidence that the reduction of GLP-1+ cells is a general feature of ileal and colonic inflammation in mice and humans and is likely due to altered epithelial differentiation driven by changes in cellular metabolism, particularly mitochondrial dysfunction.

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Although some amelioration of inflammation has been seen, these drugs did not improve the fibrosis component of NASH