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We measured the markers of cardiac hypertrophy including MYH7 and ANP, NLRP3 inflammatory signaling pathway including NLRP3, Caspase-1, and IL-18 by Western-blot, and we detected the expression MYH7, ANP, NLRP3, and IL-18 by IHC in Sham group, TAC group, TAC + semaglutide group, and TAC + semaglutide + HCQ group, respectively

[DOI] [PubMed] [Google Scholar] 77.Sanyal A.J., Bedossa P., Fraessdorf M., et al

Skipping dose increases or jumping to higher doses without medical guidance dramatically raises overdose and adverse event risk