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An analysis of CDC data also found that Black and Hispanic adults in the U.S

Some studies involving healthy subjects reported that endogenous GIP contributes to up to 25% of the suppression of bone resorption after a meal, while it found that endogenous GLP-1 has no impact on postprandial bone homeostasis [53, 54]

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Most studies were conducted in Europe and Asia, and most reported outcomes after 6 months of treatment

Similarly, tirzepatide, a dual GLP-1/GIP receptor agonist, achieved an average weight loss of 15% at 72 weeks in non-diabetic obese patients, with greater reductions observed at the higher 15 mg dose.77 The most frequently reported adverse effects of GLP-1RAs include nausea, vomiting, and diarrhea, which are dose-dependent and more prevalent with short-acting formulations than with long-acting agents

Wegovy (semaglutide 2.4mg weekly injection) carries the chronic weight management indication