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Description
Common adverse events of GLP-1RAs include nausea, vomiting, diarrhea, and constipation, with a significantly higher incidence of nausea than that of placebo [47] [48]
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O.et al

Single-receptor activation triggers these compensatory responses

Consistent with this, adenoviral overexpression of PCSK1 in -cells increases islet GLP-1 production and secretion, ultimately leading to enhanced glucose-stimulation of insulin secretion and improved survival of the islets [165]
doi:10.1016/j.neuroscience.2011.02.023 27
Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, et al
