glp 1 agonist in ckd GLP-1 Receptor Agonists and Diabetic Kidney Disease: A Call of Attention to Nephrologists GLP-1 Receptor Agonists and Kidney

Description

Dual-action GLP-1/GIP receptor agonists like Zepbound can also mimic the action of GIP, a hormone that helps regulate blood sugar levels and metabolism

weight loss at target dose (trial data) ~21% (SURMOUNT) CV risk reduction labelled Under study Format Prefilled KwikPen + single-dose autoinjector India price (May 2026) 14,00027,500/month DCGI-approved Yes (March 2025) Generic competition in India No no Indian biosimilar yet Weight-loss percentages are trial averages at target dose individual response varies

The most common side effects for all agents in this drug class are nasopharyngitis, headache, and upper respiratory tract infection

Tirzepatide treatment was also shown to produce a marked decrease in the levels of large and small triglyceride-rich lipoproteins such as diacylglycerol, phosphatidylethanolamines, and phosphatidylcholines [19]

Efficacy and Safety of Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg in Metformin-Treated Patients With Type 2 Diabetes in a Randomized Controlled Trial (AWARD-11)