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Neither medication is clearly faster in overall onset

Side effects do tend to be more intense right after the weekly shot and whenever your dose goes up, so after you settle in at your final dose level, the side effects may dissipate or linger at a lower and more tolerable level, Kushner says

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Core symptoms of depression include: Persistent low mood or sadness lasting most of the day, nearly every day, for at least two weeks Loss of interest or pleasure (anhedonia) in activities previously enjoyed Fatigue or loss of energy , even with adequate rest Changes in appetite or weight (beyond expected Mounjaro-related weight loss) Sleep disturbances (insomnia or hypersomnia) Difficulty concentrating or making decisions Feelings of worthlessness or excessive guilt Recurrent thoughts of death or suicidal ideation It can be challenging to distinguish between medication side effects and depression

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How Wegovy Affects Your Digestive System Wegovy exerts its weight-loss effects through multiple mechanisms, with significant impact on the gastrointestinal system