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Footnotes Declaration of conflicting interests The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: George Perry is an Editor-in-Chief of this journal but was not involved in the peer-review process of this article nor had access to any information regarding its peer-review

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Thyroid function tests (TSH, T3, T4) are particularly relevant for semaglutide patients, as thyroid conditions are both a common contributor to weight management difficulty and a consideration for treatment eligibility

Developed by Eli Lilly, retatrutide is a triple hormone receptor agonist (GLP-1, GIP and glucagon)

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Who Should Choose Compounded Semaglutide Compounded semaglutide is the better fit for patients without insurance coverage for Wegovy, those paying fully out of pocket, patients who want dose flexibility during titration, or anyone for whom the cost difference between the two options is the deciding factor in whether treatment is sustainable long-term