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The cardiovascular safety and efficacy of tirzepatide in adults with T2D has been assessed in a large phase 3 clinical trial (SURPASS-CVOT) (Table 1) [88]

The side effect profiles of these medications also connect to the expiration discussion

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With this evolving backdrop, this perspective article aims to explore the biological and clinical activities of tirzepatide, denifanstat, semaglutide, dapagliflozin, and efruxifermin, for which robust evidence of activity has been published

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