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Since fasting insulin (among other things) is not tested routinely despite the prevalence of insulin resistance, a significant proportion of people may go undiagnosed, and the condition may progress gradually for years

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As of 2026, Wegovy is not reimbursed under the General Medical Services (GMS) scheme or the Drug Payment Scheme (DPS) in Ireland

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Tirzepatide is the appropriate choice for studying GLP-1/GIP co-agonism because GIP recruitment is hypothesised to improve adipocyte lipid handling independently of GLP-1, isolating the incremental contribution of the second incretin arm

They also delay gastric emptying, which helps control both appetite and postprandial (after a meal) blood sugar levels